Preheat the oven to 350°F. Spray a deep 8-inch pie plate with cooking spray.
In a large mixing bowl, add the granulated sugar, Bisquick, softened butter, evaporated milk, eggs, pumpkin puree, pumpkin pie spice, and vanilla extract.
Mix with a hand mixer until smooth and well blended, about 2 minutes.
Pour the batter into the prepared pie plate.
Bake for 55 to 60 minutes, or until a knife inserted in the center comes out clean.
Remove from the oven and let rest about 30 minutes before slicing. Serve warm or cold, topped with whipped topping if desired.